Publications

He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proc Natl Acad Sci U S A. pii: 201715363. doi: 10.1073/pnas.1715363114.

Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP.(2017) Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. pii: 201619119. doi: 10.1073/pnas.1619119114.

Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. (2017) NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 8(1):959. PMCID: PMC5643384.

Zheng Y. (2017) A Rogue Foxp3 Mutant Undermines Treg Cell Function. Immunity. 47(2):211-214.

Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT. (2017) Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 198(12):4639-4651. PMCID: PMC5507362.

Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol. 17(11):1322-1333. PMCID: PMC5071159

Liu WH, Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y, Lu LF, Xiao N, Fu G, Xiao C. (2016) A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med. 213(9):1901-19. PMCID: PMC4995083

Bapat SP, Suh JM, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RE and Zheng Y. (2015) Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528, 137–141.

Li X and Zheng Y. (2015) Regulatory T cell identity: formation and maintenance. Trends in Immunology 36(6):344-353.

Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, and Montminy M. (2015) The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nat Commun. 6:7216.

Li X and Zheng Y. (2014) Treg identity protection by an epigenetic switch. Cell Cycle. 13(20):3159-60.

Li X, Liang Y, LeBlanc M, Benner C, and Zheng Y. (2014) Function of a Foxp3 cis-Element in Protecting Regulatory T Cell Identity. Cell 158(4):734–748.

Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, and Rudensky AY. (2012) Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature482(7385):395–399.

Zheng Y. ChIP-on-chip for FoxP3. (2011) Methods Mol Biol.; 707:71-82.

Zheng Y, Josefowicz SZ, Chadhry A, Peng XP, Forbush K, Rudensky AY. (2010). Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature, 463:808-12

Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY. 2009. Regulatory T cell suppressor program co-opts transcription factor IRF4 to control Th2 responses. Nature 458: 351-6

Zheng Y, Rudensky AY. 2007. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 8: 457-62

Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. 2007. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445: 936-40

Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol. 7: 401-10